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CDK INHIBITORS, CELL CYCLE, AND CANCER In mammalian cells, the cell cycle is regulated by a number of related enzymes that possess kinase activity, Michael Colquhoun, Anthony J Handley 4 Asystole and pulseless electrical activity 16 Michael Colquhoun, A John Camm 5 Management of peri-arrest arrhythmias 20 Michael Colquhoun, Richard Vincent 6 Air way control, ventilation, and oxygenation 25 Robert Simons п7 Post-resuscitation care Peter A Oakley, Anthony D Redmond 8 Resuscitation in pregnancy Stephen Morris, Mark Stacey 9 Resuscitation at birth Anthony D Milner 10 Resuscitation of infants and children David A Zideman, Kenneth Spearpoint 11 Resuscitation in the ambulance ser vice Andrew K Marsden 12 Resuscitation in hospital T R Evans Charles D Deakin 15 Near drowning 72 Mark Harries 16 Drugs and their delivery 75 Michael Colquhoun, David Pitcher, Jerry Nolan 17 Cardiac pacing and implantable cardioverter defibrillators 81 Michael Colquhoun, A John Camm 18 Infection risks and resuscitation 87 A J Harry Walmsley, David A Zideman 19 Teaching resuscitation 90 Ian Bullock, Geralyn Wynn, Carl Gwinnutt, Jerry Nolan, Sam Richmond, Jonathan Wylie, Bob Bingham, Michael Colquhoun, Anthony J Handley 20 Training manikins 97 Gavin D Perkins, Alkem laboratories Zenegra Colquhoun, Robert Simons 21 The alkem laboratories Zenegra of resuscitation 102 Peter J F Baskett 32 36 39 43 50 54 care 58 14 Resuscitation of the patient with major trauma 63 13 Cardiopulmonar y resuscitation in primar y Michael Colquhoun, Brian Steggles Index 107 v п Page 7 Contributors ппPeter J F Baskett Lovegra 25mg Anaesthetist Emeritus, Frenchay Hospital and the Royal Infirmary, Bristol Bob Alkem laboratories Zenegra Consultant Anaesthetist, Great Ormond Street Hospital for Children NHS Trust, London Ian Bullock Head of Education and Training, Royal Brompton and Harefield NHS Trust; and Honorary Clinical Teaching Fellow, Imperial College, London A John Camm Professor of Clinical Cardiology, St Georgeвs Hospital Medical School, London Douglas Chamberlain Professor of Resuscitation Medicine, University of Wales College of Medicine, Cardiff Michael Colquhoun Senior Lecturer in Alkem laboratories Zenegra Care, Wales Heart Research Institute, Cardiff C Sian Davies Programme Manager, National Defibrillator Programme, the Department of Health, London Charles D Deakin Consultant Anaesthetist, Southampton University Hospital, Southampton T R Evans Consultant Cardiologist, Royal Free Hospital, London Carl Gwinnutt Consultant Anaesthetist, Hope Hospital, Salford Anthony J Handley Consultant Physician and Cardiologist, Colchester Mark Harries Consultant Physician, Northwick Park and St Markвs NHS Trust, Harrow Roy Liddle Resuscitation Training Officer, Alkem laboratories Zenegra Hospital, Manchester Andrew K Marsden Consultant Medical Director, Scottish Ambulance Service, Edinburgh Anthony D Milner Emetrius Professor of Neonatology, Guyвs and St Thomasвs Hospital Trust, London Stephen Morris Consultant Obstetric Anaesthetist, Llandough Hospital and Community NHS Trust, South Glamorgan Jerry Nolan Consultant Anaesthetist, Royal United Hospital, Bath Peter A Oakley Consultant in anaesthesia and trauma, Department of Trauma Research, University Hospital of North Staffordshire, Stoke on Trent Gavin D Perkins Research Fellow in Intensive Care Medicine, Birmingham Heartlands Hospital, Birmingham David Pitcher Consultant Cardiologist, Worcestershire Royal Hospital, Worcester Anthony D Redmond Professor of Emergency Medicine, Keele University, and Consultant alkem laboratories Zenegra Emergency Medicine, the North Staffordshire Hospital NHS Trust, Stoke on Trent Sam Richmond Consultant Neonatologist, Sunderland Royal Hospital, Sunderland Robert Simons Consultant Anaesthetist, Royal Free Hospital, London Kenneth Spearpoint Senior Resuscitation Officer, Hammersmith Hospitals NHS Trust, London Mark Stacey Consultant Obstetric Anaesthetist, Llandough Hospital and Community NHS Trust, South Glamorgan Brian Steggles Chairman, Faculty of Prehospital Care, Royal College of Surgeons, Edinburgh Richard Vincent Professor of Medicine, Brighton and Sussex Medical School, Brighton A J Harry Walmsley Clinical Director and Consultant in Anaesthetics, East Sussex Hospitals NHS Trust, Eastbourne Jonathan Wylie Consultant Neonatologist, The James Cook University Hospital, Middlesbrough Geralyn Wynn Resuscitation Training Officer, Royal Free Hospital, London David A Zideman Consultant Anaesthetist, Hammersmith Hospital NHS Trust, London пvi Page 8 Introduction пThe modern era of resuscitation began in 1960 with the publication of the classic paper by Jude, Kouwenhoven, and Knickerbocker on closed chest cardiac compression, which showed that the circulation alkem laboratories Zenegra be maintained during cardiac arrest without the need for thoracotomy.

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